Blocking TGF-β- and Epithelial-to-Mesenchymal Transition (EMT)-mediated activation of brain pericytes in glioblastoma impacts tumor angiogenesis

Blocking TGF-β- and Epithelial-to-Mesenchymal Transition (EMT)-mediated activation of brain pericytes in glioblastoma impacts tumor angiogenesis

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. GBM displays excessive and unfunctional vascularization which may, among others, be a reason for its devastating prognosis. Pericytes have been identified as the major component of the irregular vessel structure in GBM....

Full description

Bibliographic Details
Main Authors: Luisa Merk, Katja Regel, Hermann Eckhardt, Marietheres Evers, Ali El-Ayoubi, Michel Mittelbronn, Marcel Krüger, Jean-Jacques Gérardy, Andreas F. Mack, Ulrike Naumann
Format: Article
Language:English
Published: University of Münster / Open Journals System 2024-03-01
Series:Free Neuropathology
Subjects:
Glioblastoma
Tumor vasculature
Pericytes
TGF-β
EMT
Online Access:https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5188

Internet

https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5188

Similar Items