ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer

ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer

Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer. NEPC is characterized by the loss of androgen receptor (AR) signaling and transdifferentiation toward small-cell neuroendocrine (SCN) phenotypes, which results in resistance to AR-targeted therapy. NEPC resemble...

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Bibliographic Details
Main Authors: Song Yi Bae, Hannah E. Bergom, Abderrahman Day, Joseph T. Greene, Zoi E. Sychev, Gabrianne Larson, Eva Corey, Stephen R. Plymate, Tanya S. Freedman, Justin H. Hwang, Justin M. Drake
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
ZBTB7A
neuroendocrine prostate cancer (NEPC)
castration-resistant prostate cancer (CRPC)
small-cell neuroendocrine (SCN)
cancer dependency map (DepMap)
RET receptor tyrosine kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1093332/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1093332/full

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