Breast-Specific Epigenetic Regulation of DeltaNp73 and Its Role in DNA-Damage-Response of <i>BRCA1</i>-Mutated Human Mammary Epithelial Cells

Breast-Specific Epigenetic Regulation of DeltaNp73 and Its Role in DNA-Damage-Response of <i>BRCA1</i>-Mutated Human Mammary Epithelial Cells

The function of BRCA1/2 proteins is essential for maintaining genomic integrity in all cell types. However, why women who carry deleterious germline mutations in <i>BRCA</i> face an extremely high risk of developing breast and ovarian cancers specifically has remained an enigma. We propo...

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Bibliographic Details
Main Authors: Ayelet Avraham, Susanna Feldman, Sean Soonweng Cho, Ayala Kol, Lior Heler, Emmanuela Riklin-Nahmias, Avishay Sella, Tamar Karni, Tanir M. Allweis, Saraswati Sukumar, Ella Evron
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
<i>BRCA</i>-mutation
cancer susceptibility
deltaNp73
DNA methylation
tissue-specificity
Online Access:https://www.mdpi.com/2072-6694/12/9/2367

Internet

https://www.mdpi.com/2072-6694/12/9/2367

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