Lysosomal iron accumulation and subsequent lysosomes-mitochondria iron transmission mediate PFOS-induced hepatocyte ferroptosis

Lysosomal iron accumulation and subsequent lysosomes-mitochondria iron transmission mediate PFOS-induced hepatocyte ferroptosis

Perfluorooctane sulfonate (PFOS) is known as a persistent organic pollutant. A significant correlation between PFOS and liver ferroptosis has been unveiled, but the precise mechanism needs to be elucidated. In prior research, we found that PFOS treatment provoked mitochondrial iron overload. In this...

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Bibliographic Details
Main Authors: Jixun Li, Ruzhen Feng, Wei Yang, Peiyao Liang, Tianming Qiu, Jingyuan Zhang, Xiance Sun, Qiujuan Li, Guang Yang, Xiaofeng Yao
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Ferroptosis
PFOS
Lysosomal iron
Mitochondrial iron
Voltage-dependent anion-selective channel 3
Transient receptor potential mucolipin 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324009667

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http://www.sciencedirect.com/science/article/pii/S0147651324009667

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