Development and Validation of an LC-MS/MS Assay to Quantitate 2′,4′,6′-Trihydroxyacetophenone in Rat and Dog Plasma and its Application to a Pharmacokinetic Study

Development and Validation of an LC-MS/MS Assay to Quantitate 2′,4′,6′-Trihydroxyacetophenone in Rat and Dog Plasma and its Application to a Pharmacokinetic Study

In the present study, a simple, rapid, and reliable bioanalytical method was developed using liquid chromatography with tandem-mass spectrometry (LC-MS/MS) to quantify 2′,4′,6′-trihydroxyacetophenone (THAP) in rat and dog plasma with 2′,4′,6′-trihydroxybenzaldehyde as an internal standard (IS). The...

Full description

Bibliographic Details
Main Authors: Hee Jo Yoo, Se-Jung Hwang, Jeong-Hun Lee, Wang-Seob Shim, Yun-Woong Choi, Sang Min Cho, Eun Kyoung Chung, Jun-Bom Park, Kyung-Tae Lee
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
2′,4′,6′-trihydroxyacetophenone
LC-MS/MS
validation
pharmacokinetic study
polo-like kinase 1
Online Access:https://www.mdpi.com/1420-3049/25/19/4373

Internet

https://www.mdpi.com/1420-3049/25/19/4373

Similar Items