Amplification of 3q26.2, 5q14.3, 8q24.3, 8q22.3, and 14q32.33 Are Possible Common Genetic Alterations in Oral Cancer Patients

Amplification of 3q26.2, 5q14.3, 8q24.3, 8q22.3, and 14q32.33 Are Possible Common Genetic Alterations in Oral Cancer Patients

The lack of clinical biomarkers for head and neck cancer subtypes limits early diagnosis and monitoring of disease progression. This study investigates genetic alterations in clinically identical tumor, tumor-adjacent dysplastic epithelium (TADE) and normal epithelium (NE) in five oral cancer patien...

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Bibliographic Details
Main Authors: Melvin A. Ambele, Andre van Zyl, Michael S. Pepper, Marlene B. van Heerden, Willie F. P. van Heerden
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
oral squamous cell carcinomas
head and neck cancer
genomic heterogeneity
intratumor clonal heterogeneity
intertumoral clonal diversity
OncoScan® FFPE assay
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00683/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00683/full

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