Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment

Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment

Summary: The axon initial segment (AIS) is the site of action potential initiation and serves as a cargo transport filter and diffusion barrier that helps maintain neuronal polarity. The AIS actin cytoskeleton comprises actin patches and periodic sub-membranous actin rings. We demonstrate that tropo...

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Bibliographic Details
Main Authors: Amr Abouelezz, Holly Stefen, Mikael Segerstråle, David Micinski, Rimante Minkeviciene, Lauri Lahti, Edna C. Hardeman, Peter W. Gunning, Casper C. Hoogenraad, Tomi Taira, Thomas Fath, Pirta Hotulainen
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Biological Sciences
Molecular Neuroscience
Cellular Neuroscience
Cell Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302388

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http://www.sciencedirect.com/science/article/pii/S2589004220302388

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