The Microtubule Plus-End Tracking Protein CLASP2 Is Required for Hematopoiesis and Hematopoietic Stem Cell Maintenance

The Microtubule Plus-End Tracking Protein CLASP2 Is Required for Hematopoiesis and Hematopoietic Stem Cell Maintenance

Mammalian CLASPs are microtubule plus-end tracking proteins whose essential function as regulators of microtubule behavior has been studied mainly in cultured cells. We show here that absence of murine CLASP2 in vivo results in thrombocytopenia, progressive anemia, and pancytopenia, due to defects i...

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Bibliographic Details
Main Authors: Ksenija Drabek, Laura Gutiérrez, Marcel Vermeij, Thomas Clapes, Sunita R. Patel, Jean-Charles Boisset, Jeffrey van Haren, Ana L. Pereira, Zhe Liu, Umut Akinci, Tatjana Nikolic, Wilfred van IJcken, Mirjam van den Hout, Marjolein Meinders, Clara Melo, Clara Sambade, Dubravka Drabek, Rudi W. Hendriks, Sjaak Philipsen, Mieke Mommaas, Frank Grosveld, Helder Maiato, Joseph E. Italiano, Jr., Catherine Robin, Niels Galjart
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712002811

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http://www.sciencedirect.com/science/article/pii/S2211124712002811

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