HAND factors regulate cardiac lineage commitment and differentiation from human pluripotent stem cells

HAND factors regulate cardiac lineage commitment and differentiation from human pluripotent stem cells

Abstract Background Transcription factors HAND1 and HAND2 (HAND1/2) play significant roles in cardiac organogenesis. Abnormal expression and deficiency of HAND1/2 result in severe cardiac defects. However, the function and mechanism of HAND1/2 in regulating human early cardiac lineage commitment and...

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Bibliographic Details
Main Authors: Huixin Guo, Chengwen Hang, Bowen Lin, Zheyi Lin, Hui Xiong, Mingshuai Zhang, Renhong Lu, Junyang Liu, Dan Shi, Duanyang Xie, Yi Liu, Dandan Liang, Jian Yang, Yi-Han Chen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Stem Cell Research & Therapy
Subjects:
HAND1
HAND2
Human pluripotent stem cells
Cardiac lineage commitment
Cardiomyocyte differentiation
TBX5
Online Access:https://doi.org/10.1186/s13287-024-03649-9

Internet

https://doi.org/10.1186/s13287-024-03649-9

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