CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

Abstract Background Immune inhibitory receptors play an important role in chronic infections. However, little is known about their role in hepatitis B virus (HBV) infection. Here, we analyzed the relationship between programmed death-1 (PD-1) and lymphocyte activation gene-3 (LAG-3) expression on CD...

Full description

Bibliographic Details
Main Authors: Yuejiao Dong, Xuefen Li, Lu Zhang, Qiaoyun Zhu, Chunlei Chen, Jiaqi Bao, Yu Chen
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Immunology
Subjects:
CD4+ T cells
Chronic HBV infection
Inhibitory molecules
Programmed death 1 (PD-1)
Lymphocyte activation gene-3 (LAG-3)
Cytokine
Online Access:http://link.springer.com/article/10.1186/s12865-019-0309-9

Internet

http://link.springer.com/article/10.1186/s12865-019-0309-9

Similar Items