Differential cardiomyocyte transcriptomic remodeling during in vitro Trypanosoma cruzi infection using laboratory strains provides implications on pathogenic host responses

Differential cardiomyocyte transcriptomic remodeling during in vitro Trypanosoma cruzi infection using laboratory strains provides implications on pathogenic host responses

Abstract Background Chagas disease can lead to life-threatening cardiac manifestations. Regional factors, including genetic characteristics of circulating Trypanosoma cruzi (T. cruzi), have attracted attention as likely determinants of Chagas disease phenotypic expression and Chagas cardiomyopathy (...

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Main Authors: Katherine-Sofia Candray-Medina, Yu Nakagama, Masamichi Ito, Shun Nakagama, Evariste Tshibangu-Kabamba, Norihiko Takeda, Yuki Sugiura, Yuko Nitahara, Yu Michimuko-Nagahara, Natsuko Kaku, Yoko Onizuka, Carmen-Elena Arias, Maricela Mejia, Karla Alas, Susana Peña, Yasuhiro Maejima, Issei Komuro, Junko Nakajima-Shimada, Yasutoshi Kido
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Tropical Medicine and Health
Subjects:
Trypanosoma cruzi
Chagas disease
Transcriptome
HL-1
In vitro modeling
Dilated cardiomyopathy
Online Access:https://doi.org/10.1186/s41182-023-00552-6

Internet

https://doi.org/10.1186/s41182-023-00552-6

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