Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals

Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals

Cell-penetrating peptides (CPPs) have great potential to efficiently deliver drug cargos across cell membranes without cytotoxicity. Cationic arginine and hydrophobic tryptophan have been reported to be key component amino acids for cellular internalization of CPPs. We recently found that l-arginine...

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Bibliographic Details
Main Authors: Noriyasu Kamei, Hideyuki Tamiwa, Mari Miyata, Yuta Haruna, Koyo Matsumura, Hideyuki Ogino, Serena Hirano, Kazuhiro Higashiyama, Mariko Takeda-Morishita
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceutics
Subjects:
tryptophan
oral delivery
insulin
GLP-1
intestinal absorption
amino acid
cell-penetrating peptide
Online Access:http://www.mdpi.com/1999-4923/10/4/182

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http://www.mdpi.com/1999-4923/10/4/182

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