SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal GutSummary

SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal GutSummary

Background & Aims: Single immunoglobulin interleukin-1–related receptor (SIGIRR) is a major inhibitor of Toll-like receptor signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who died of severe necrotizing enterocolitis (NEC). Herein, we investigated the...

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Bibliographic Details
Main Authors: Wei Yu, Inamul Haque, Aparna Venkatraman, Heather L. Menden, Sherry M. Mabry, Badal C. Roy, Sheng Xia, Jeremy W. Prokop, Shahid Umar, Aron M. Geurts, Venkatesh Sampath
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
SIGIRR
microRNA
STAT3
Intestinal Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X21001971

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http://www.sciencedirect.com/science/article/pii/S2352345X21001971

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