AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?

AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?

The serine/threonine kinase AKT is a key component of the PI3K/AKT/mTOR signaling pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism. Deregulation of this pathway is a common event in breast cancer including hormone receptor-positive (HR+) disease, HER2-ampli...

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Bibliographic Details
Main Authors: Federica Martorana, Gianmarco Motta, Giuliana Pavone, Lucia Motta, Stefania Stella, Silvia Rita Vitale, Livia Manzella, Paolo Vigneri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
breast cancer
AKT inhibitors
targeted therapy
PI3K/AKT/mTOR pathway
clinical trials
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.662232/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.662232/full

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