Individual cells generate their own self-reinforcing contact guidance cues through local matrix fiber remodeling.

Individual cells generate their own self-reinforcing contact guidance cues through local matrix fiber remodeling.

Directed cell migration arises from cells following a microenvironmental gradient (e.g. of a chemokine) or polarizing feature (e.g. a linear structure). However cells not only follow, but in many cases, also generate directionality cues by modifying their microenvironment. This bi-directional relati...

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Bibliographic Details
Main Authors: Michael Pamonag, Abigail Hinson, Elisha J Burton, Nojan Jafari, Dominic Sales, Sarah Babcock, Rozlan Basha, Xiaofeng Hu, Kristopher E Kubow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0265403

Internet

https://doi.org/10.1371/journal.pone.0265403

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