hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS)

hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS)

Abstract Neurodegeneration is the primary driver of disease progression in multiple sclerosis (MS) resulting in permanent disability, creating an urgent need to discover its underlying mechanisms. Herein, we establish that dysfunction of the RNA binding protein heterogeneous nuclear ribonucleoprotei...

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Bibliographic Details
Main Authors: Hannah E. Salapa, Patricia A. Thibault, Cole D. Libner, Yulian Ding, Joseph-Patrick W. E. Clarke, Connor Denomy, Catherine Hutchinson, Hashim M. Abidullah, S. Austin Hammond, Landon Pastushok, Frederick S. Vizeacoumar, Michael C. Levin
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44658-1

Internet

https://doi.org/10.1038/s41467-023-44658-1

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