Novel inhibitors that target bacterial virulence identified via HTS against intra-macrophage survival of Shigella flexneri

Novel inhibitors that target bacterial virulence identified via HTS against intra-macrophage survival of Shigella flexneri

Shigella flexneri is a facultative intracellular pathogen that causes shigellosis, a human diarrheal disease characterized by the destruction of the colonic epithelium. Novel antimicrobial compounds to treat infections are urgently needed due to the proliferation of bacterial antibiotic resistance a...

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Bibliographic Details
Main Authors: Marija Miljkovic, Sonia Lozano, Isabel Castellote, Cristina de Cózar, Ana I. Villegas-Moreno, Pablo Gamallo, Dolores Jimenez-Alfaro Martinez, Elena Fernández-Álvaro, Lluis Ballell, George A. Garcia
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mSphere
Subjects:
Shigella flexneri 2457T
shigellosis
high-throughput screening
THP-1 macrophages
intracellular
virulence
Online Access:https://journals.asm.org/doi/10.1128/msphere.00154-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00154-23

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