Integrated untargeted and targeted metabolomics to reveal therapeutic effect and mechanism of Alpiniae oxyphyllae fructus on Alzheimer’s disease in APP/PS1 mice

Integrated untargeted and targeted metabolomics to reveal therapeutic effect and mechanism of Alpiniae oxyphyllae fructus on Alzheimer’s disease in APP/PS1 mice

Introduction:Alpiniae oxyphyllae Fructus (AOF) has been abundantly utilized for the treatment of diarrhea, dyspepsia, kidney asthenia, and abdominal pain in China. AOF is effective for treating AD in clinical trials, but its exact mode of action is yet unknown.Methods: In this study, metabolomics wa...

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Bibliographic Details
Main Authors: Shengnan Zhou, Liwei Liu, Yuanyuan Zhang, Zhibo Zhang, Hanbing Li, Feng Fan, Jiuming He, Jian Kang, Lihua Zuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
Alpiniae oxyphyllae fructus
alzheimer’s disease
untargeted metabolomics
targeted metabolomics
bile acids
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1104954/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1104954/full

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