The location of the axon initial segment affects the bandwidth of spike initiation dynamics.

The dynamics and the sharp onset of action potential (AP) generation have recently been the subject of intense experimental and theoretical investigations. According to the resistive coupling theory, an electrotonic interplay between the site of AP initiation in the axon and the somato-dendritic loa...

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Bibliographic Details
Main Authors: Christophe Verbist, Michael G Müller, Huibert D Mansvelder, Robert Legenstein, Michele Giugliano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008087