Direct Capsid Labeling of Infectious HIV-1 by Genetic Code Expansion Allows Detection of Largely Complete Nuclear Capsids and Suggests Nuclear Entry of HIV-1 Complexes via Common Routes

Direct Capsid Labeling of Infectious HIV-1 by Genetic Code Expansion Allows Detection of Largely Complete Nuclear Capsids and Suggests Nuclear Entry of HIV-1 Complexes via Common Routes

ABSTRACT The cone-shaped mature HIV-1 capsid is the main orchestrator of early viral replication. After cytosolic entry, it transports the viral replication complex along microtubules toward the nucleus. While it was initially believed that the reverse transcribed genome is released from the capsid...

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Bibliographic Details
Main Authors: Sandra Schifferdecker, Vojtech Zila, Thorsten G. Müller, Volkan Sakin, Maria Anders-Össwein, Vibor Laketa, Hans-Georg Kräusslich, Barbara Müller
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
HIV-1
capsid
click labeling
amber suppression
genetic code expansion
primary CD4+ T cells
Online Access:https://journals.asm.org/doi/10.1128/mbio.01959-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01959-22

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