Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving cytotoxic conformations of Cu, Zn superoxide dismutase (SOD1). A major challenge in understanding ALS disease pathology has been the identification and atomic-level characterization of these conformers. Here, we...

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Bibliographic Details
Main Authors: Ashok Sekhar, Jessica AO Rumfeldt, Helen R Broom, Colleen M Doyle, Guillaume Bouvignies, Elizabeth M Meiering, Lewis E Kay
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-06-01
Series:eLife
Subjects:
human Cu, Zn superoxide dismutase
CPMG relaxation dispersion
non-native oligomer
transient conformation
CEST
protein aggregation
Online Access:https://elifesciences.org/articles/07296

Internet

https://elifesciences.org/articles/07296

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