Longitudinal multi-omics alterations response to 8-week risperidone monotherapy: Evidence linking cortical thickness, transcriptomics and epigenetics

Longitudinal multi-omics alterations response to 8-week risperidone monotherapy: Evidence linking cortical thickness, transcriptomics and epigenetics

BackgroundAntipsychotic treatment-related alterations of cortical thickness (CT) and clinical symptoms have been previously corroborated, but less is known about whether the changes are driven by gene expression and epigenetic modifications.MethodsUtilizing a prospective design, we recruited 42 trea...

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Bibliographic Details
Main Authors: Xiaofen Zong, Gaohua Wang, Zhaowen Nie, Simeng Ma, Lijun Kang, Nan Zhang, Shenhong Weng, Qing Tan, Junjie Zheng, Maolin Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Psychiatry
Subjects:
Allen Human Brain Atlas
risperidone
schizophrenia
magnetic resonance imaging
cortical thickness
DNA methylation
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1127353/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1127353/full

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