Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma

Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma

Abstract Background Sorafenib improves the overall survival in patients with advanced hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) is commonly overexpressed in HCC. In this study, we investigated whether the inhibition of DKK1 enhances the anti-tumor efficacy of sorafenib in HCC. Methods HCC ce...

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Bibliographic Details
Main Authors: Sang Hyun Seo, Kyung Joo Cho, Hye Jung Park, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jae Hee Cheon, Jong In Yook, Man-Deuk Kim, Dong Jin Joo, Seung Up Kim
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell Communication and Signaling
Subjects:
Dickkopf-1
Sorafenib
Hepatocellular carcinoma
Phosphatidylinositol-3-kinase/protein kinase B pathway
Wnt/β-catenin pathway
GSK3β
Online Access:https://doi.org/10.1186/s12964-023-01355-2

Internet

https://doi.org/10.1186/s12964-023-01355-2

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