Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.

Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.

Homologous recombination (HR) is initiated by DNA double-strand breaks (DSB). However, it remains unclear whether single-strand lesions also initiate HR in genomic DNA. Chicken B lymphocytes diversify their Immunoglobulin (Ig) V genes through HR (Ig gene conversion) and non-templated hypermutation....

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Bibliographic Details
Main Authors: Makoto Nakahara, Eiichiro Sonoda, Kuniharu Nojima, Julian E Sale, Katsuya Takenaka, Koji Kikuchi, Yoshihito Taniguchi, Kyoko Nakamura, Yoshiki Sumitomo, Ronan T Bree, Noel F Lowndes, Shunichi Takeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2625440?pdf=render

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http://europepmc.org/articles/PMC2625440?pdf=render

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