CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer

CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer

Epithelial ovarian cancer (EOC) is the deadliest of the gynecologic malignancies, with an overall survival rate of <30%. Recent research has suggested that targeting RNA polymerase I (POL I) with small-molecule inhibitors may be a viable therapeutic approach to combating EOC, even when chemoresis...

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Bibliographic Details
Main Authors: Robert Cornelison, Kuntal Biswas, Danielle C. Llaneza, Alexandra R. Harris, Nisha G. Sosale, Matthew J. Lazzara, Charles N. Landen
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
ovarian cancer
ribosomal synthesis
RNA polymerase I
CX-5461
chemoresistance
patient-derived xenograft
Online Access:https://www.mdpi.com/2072-6694/13/20/5056

Internet

https://www.mdpi.com/2072-6694/13/20/5056

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