β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice

β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice

Objective: Notch signaling, re-activated in β cells from obese mice and causal to β cell dysfunction, is determined in part by transmembrane ligand availability in a neighboring cell. We hypothesized that β cell expression of Jagged1 determines the maladaptive Notch response and resultant insulin se...

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Bibliographic Details
Main Authors: Nina Suda, Alberto Bartolomé, Jiani Liang, Jinsook Son, Yoko Yagishita, Christian Siebel, Domenico Accili, Hongxu Ding, Utpal B. Pajvani
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Metabolism
Subjects:
Notch
Jagged1
Beta cell
Alpha cell
Insulin secretion
Diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000255

Internet

http://www.sciencedirect.com/science/article/pii/S2212877824000255

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