Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis

Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis

Abstract Background Most current disease-modifying therapies approved for multiple sclerosis (MS) are immunomodulatory drugs that counteract the aberrant activity of the immune system. Hence, new pharmacological interventions that drive anti-inflammatory activity and neuroprotection would represent...

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Bibliographic Details
Main Authors: Alejandro Torrillas-de la Cal, Sonia Torres-Sanchez, Lidia Bravo, Meritxell Llorca-Torralba, Jose Antonio Garcia-Partida, Ana I. Arroba, Esther Berrocoso
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Locus coeruleus
Noradrenaline
Spinal cord
Online Access:https://doi.org/10.1186/s12974-023-02865-z

Internet

https://doi.org/10.1186/s12974-023-02865-z

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