A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice

Parkinson’s disease (PD) is a movement disorder characterized by neuroinflammation, α-synuclein pathology, and neurodegeneration. Most cases of PD are non-hereditary, suggesting a strong role for environmental factors, and it has been speculated that disease may originate in peripheral tissues such...

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Bibliographic Details
Main Authors: Reem Abdel-Haq, Johannes CM Schlachetzki, Joseph C Boktor, Thaisa M Cantu-Jungles, Taren Thron, Mengying Zhang, John W Bostick, Tahmineh Khazaei, Sujatha Chilakala, Livia H Morais, Greg Humphrey, Ali Keshavarzian, Jonathan E Katz, Matthew Thomson, Rob Knight, Viviana Gradinaru, Bruce R Hamaker, Christopher K Glass, Sarkis K Mazmanian
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
parkinson's disease
diet
microglia
microbiome
Online Access:https://elifesciences.org/articles/81453

Internet

https://elifesciences.org/articles/81453

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