Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA

Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA

Quantification of tumor‐specific variants (TSVs) in cell‐free DNA is rapidly evolving as a prognostic and predictive tool in patients with cancer. Currently, both variant allele frequency (VAF) and number of mutant molecules per mL plasma are used as units of measurement to report those TSVs. Howeve...

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Bibliographic Details
Main Authors: Manouk K. Bos, Kazem Nasserinejad, Maurice P. H. M. Jansen, Christi M.J. Steendam, Lindsay Angus, Peggy N. Atmodimedjo, Evert deJonge, Winand N. M. Dinjens, Ron H. N. vanSchaik, Marzia Del Re, Hendrikus J. Dubbink, Stefan Sleijfer, John W. M. Martens
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Molecular Oncology
Subjects:
cancer
circulating tumor DNA
digital droplet PCR
liquid biopsy
next‐generation sequencing
unit of measurement
Online Access:https://doi.org/10.1002/1878-0261.12827

Internet

https://doi.org/10.1002/1878-0261.12827

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