Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction

Polymeric immunoglobulin receptor deficiency exacerbates autoimmune hepatitis by inducing intestinal dysbiosis and barrier dysfunction

Abstract Autoimmune hepatitis (AIH) is an immune-mediated inflammatory liver disease with unclear pathogenesis. The gut microbiota and intestinal barrier play an essential role in AIH. Polymeric immunoglobulin receptor (pIgR) is a central component of mucosal immunity. Herein, we aimed to test the h...

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Bibliographic Details
Main Authors: Hongwei Lin, Jing Lin, Tongtong Pan, Ting Li, Huimian Jiang, Yan Fang, Yuxin Wang, Faling Wu, Jia Huang, Huadong Zhang, Dazhi Chen, Yongping Chen
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05589-3

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https://doi.org/10.1038/s41419-023-05589-3

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