Adrenergic Blockade by Nebivolol to Suppress Oral Squamous Cell Carcinoma Growth via Endoplasmic Reticulum Stress and Mitochondria Dysfunction

Adrenergic Blockade by Nebivolol to Suppress Oral Squamous Cell Carcinoma Growth via Endoplasmic Reticulum Stress and Mitochondria Dysfunction

Adrenergic nerve fibers in the tumor microenvironment promote tumor growth and represent a potential target for cancer therapy. However, the effectiveness of targeting adrenergic nerve fibers for oral squamous cell carcinoma (OSCC) therapy needs to be evaluated by preclinical data. Herein, the 4NQO-...

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Bibliographic Details
Main Authors: Qian Chen, Han Jiang, Zhen Wang, Lu-Yao Cai, Yu-Chen Jiang, Liang Xie, Yu Zhou, Xin Zeng, Ning Ji, Ying-Qiang Shen, Qian-Ming Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
nebivolol
oral squamous cell carcinoma cells
endoplasmic reticulum stress
mitochondria
autonomic nerve
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.691998/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.691998/full

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