DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD

DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD

Abstract Background Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading cause of HCC-related death. However, the currently available treatment strategies for efficient suppression of metastasis are limited. Therefore, novel thera...

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Bibliographic Details
Main Authors: Yang-ling Li, Man-man Zhang, Lin-wen Wu, Ye-han Liu, Zuo-yan Zhang, Ling-hui Zeng, Neng-ming Lin, Chong Zhang
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Biomedical Science
Subjects:
Hepatocellular carcinoma
DYRK1A
EMT
Metastasis
TSC1
Online Access:https://doi.org/10.1186/s12929-022-00817-y

Internet

https://doi.org/10.1186/s12929-022-00817-y

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