Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1

Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1

Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumst...

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Bibliographic Details
Main Authors: Amanda Agazio, Jennifer Cimons, Kristin M. Shotts, Kejun Guo, Mario L. Santiago, Roberta Pelanda, Raul M. Torres
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
B cells
peripheral tolerance
autoreactive
polyreactive
HIV-1
bnAbs
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01565/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01565/full

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