Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma

Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma

Cancer cells gain drug resistance through a complex mechanism, in which nuclear factor-κB (NF-κB) and interleukin-1β (IL-1β) are critical contributors. Because NACHT, LRR and PYD domains-containing protein (NLRP) inflammasomes mediate IL-1β maturation and NF-κB activation, we investigated the role o...

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Bibliographic Details
Main Authors: Zili Zhai, Jenny Mae Samson, Takeshi Yamauchi, Prasanna K. Vaddi, Yuko Matsumoto, Charles A. Dinarello, Dinoop Ravindran Menon, Mayumi Fujita
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
melanoma
inflammasome
NLRP1
acquired resistance
chemotherapy
Online Access:https://www.mdpi.com/2072-6694/12/9/2518

Internet

https://www.mdpi.com/2072-6694/12/9/2518

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