Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells

Thymosin beta-4 improves endothelial function and reparative potency of diabetic endothelial cells differentiated from patient induced pluripotent stem cells

Abstract Background Prior studies show that signature phenotypes of diabetic human induced pluripotent stem cells derived endothelial cells (dia-hiPSC-ECs) are disrupted glycine homeostasis, increased senescence, impaired mitochondrial function and angiogenic potential as compared with healthy hiPSC...

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Bibliographic Details
Main Authors: Liping Su, Xiaocen Kong, Szejie Loo, Yu Gao, Bingli Liu, Xiaofei Su, Rinkoo Dalan, Jianhua Ma, Lei Ye
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Stem Cell Research & Therapy
Subjects:
Endothelium
Endothelial function
Senescence
Mitochondrial function
Thymosin
Online Access:https://doi.org/10.1186/s13287-021-02687-x

Internet

https://doi.org/10.1186/s13287-021-02687-x

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