Characterizing hedgehog pathway features in senescence associated osteoarthritis through Integrative multi-omics and machine learning analysis

Characterizing hedgehog pathway features in senescence associated osteoarthritis through Integrative multi-omics and machine learning analysis

Purpose: Osteoarthritis (OA) is a disease of senescence and inflammation. Hedgehog’s role in OA mechanisms is unclear. This study combines Bulk RNA-seq and scRNA-seq to identify Hedgehog-associated genes in OA, investigating their impact on the pathogenesis of OA.Materials and methods: Download and...

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Bibliographic Details
Main Authors: Tao Wang, Zhengrui Li, Shijian Zhao, Ying Liu, Wenliang Guo, Raquel Alarcòn Rodrìguez, Yinteng Wu, Ruqiong Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Genetics
Subjects:
hedgehog
osteoarthritis (OA)
senescence
bulk RNA sequencing (bulk-RNA seq)
single-cell RNA sequencing (scRNA-seq)
immune cell infiltration
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1255455/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2024.1255455/full

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