Redox-Cycling “Mitocans” as Effective New Developments in Anticancer Therapy

Redox-Cycling “Mitocans” as Effective New Developments in Anticancer Therapy

Our study proposes a pharmacological strategy to target cancerous mitochondria via redox-cycling “mitocans” such as quinone/ascorbate (Q/A) redox-pairs, which makes cancer cells fragile and sensitive without adverse effects on normal cells and tissues. Eleven Q/A redox-pairs were tested on cultured...

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Bibliographic Details
Main Authors: Rumiana Bakalova, Dessislava Lazarova, Akira Sumiyoshi, Sayaka Shibata, Zhivko Zhelev, Biliana Nikolova, Severina Semkova, Tatyana Vlaykova, Ichio Aoki, Tatsuya Higashi
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
quinones
ascorbate
cancer
mitochondria
redox-cycling
prenylation
Online Access:https://www.mdpi.com/1422-0067/24/9/8435

Internet

https://www.mdpi.com/1422-0067/24/9/8435

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