Astragalus polysaccharide restores insulin secretion impaired by lipopolysaccharides through the protein kinase B /mammalian target of rapamycin/glucose transporter 2 pathway

Astragalus polysaccharide restores insulin secretion impaired by lipopolysaccharides through the protein kinase B /mammalian target of rapamycin/glucose transporter 2 pathway

Abstract Background Lipopolysaccharide (LPS)-induced dysfunction of pancreatic β-cells leads to impaired insulin (INS) secretion. Astragalus polysaccharide (APS) is a bioactive heteropolysaccharide extracted from Astragalus membranaceus and is a popular Chinese herbal medicine. This study aimed to e...

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Bibliographic Details
Main Authors: Xiaodan Ren, Ying Dai, Mengya Shan, Jing Zheng, Zhongyi Zhang, Tao Shen
Format: Article
Language:English
Published: BMC 2023-10-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Astragalus polysaccharide
Lipopolysaccharides
Insulin secretion
Glucose transporter 2
Online Access:https://doi.org/10.1186/s12906-023-04188-1

Internet

https://doi.org/10.1186/s12906-023-04188-1

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