MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

Abstract Necroptosis is known to play an important role in the pathophysiology of cerebral ischemia; however, its role in the occurrence of secondary thalamic injury after focal cerebral infarction and the mechanism about how mixed lineage kinase domain-like (MLKL) executes necroptosis in this patho...

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Bibliographic Details
Main Authors: Yanyan Tang, Quanhong Chu, Guanfeng Xie, Yafu Tan, Ziming Ye, Chao Qin
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Molecular Brain
Subjects:
Cerebral infarction
Secondary damage
Necroptosis
MLKL
Cx43
Online Access:https://doi.org/10.1186/s13041-023-01064-4

Internet

https://doi.org/10.1186/s13041-023-01064-4

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