Direct cardiac effects of SGLT2 inhibitors

Direct cardiac effects of SGLT2 inhibitors

Abstract Sodium-glucose-cotransporter 2 inhibitors (SGLT2is) demonstrate large cardiovascular benefit in both diabetic and non-diabetic, acute and chronic heart failure patients. These inhibitors have on-target (SGLT2 inhibition in the kidney) and off-target effects that likely both contribute to th...

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Bibliographic Details
Main Authors: Sha Chen, Ruben Coronel, Markus W. Hollmann, Nina C. Weber, Coert J. Zuurbier
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Cardiovascular Diabetology
Subjects:
Sodium-glucose-cotransporter 2 inhibitors
Ion homeostasis
Oxidative stress
Inflammation
Metabolism
Cardiac function
Online Access:https://doi.org/10.1186/s12933-022-01480-1

Internet

https://doi.org/10.1186/s12933-022-01480-1

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