Enhancing the in vivo stability of polycation gene carriers by using PEGylated hyaluronic acid as a shielding system

Enhancing the in vivo stability of polycation gene carriers by using PEGylated hyaluronic acid as a shielding system

To increase the in vivo stability of cationic gene carriers and avoid the adverse effects of their positive charge, we synthesized a new shielding material by conjugating low molecular weight polyethylene glycol (PEG) to a hyaluronic acid (HA) core. The HA-PEG conjugate assembled with the positively...

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Bibliographic Details
Main Authors: Jiaxue Liu, Xiaoli Bao, Irina Kolesnik, Boyan Jia, Zihan Yu, Caiyun Xing, Jiawen Huang, Tingting Gu, Xiaotong Shao, Alexey Kletskov, Andreii S. Kritchenkov, Vladimir Potkin, Wenliang Li
Format: Article
Language:English
Published: Compuscript Ltd 2022-09-01
Series:BIO Integration
Subjects:
peg
hyaluronic acid
stability
gene delivery
cationic gene carriers
Online Access:https://www.ingentaconnect.com/contentone/cscript/bioi/2022/00000003/00000003/art00002

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https://www.ingentaconnect.com/contentone/cscript/bioi/2022/00000003/00000003/art00002

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