Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease

Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease

Abstract Non-familial Alzheimer’s disease (AD) occurring before 65 years of age is commonly referred to as early-onset Alzheimer’s disease (EOAD) and constitutes ~ 5–6% of all AD cases (Mendez et al. in Continuum 25:34–51, 2019). While EOAD exhibits the same clinicopathological changes such as amylo...

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Bibliographic Details
Main Authors: Phoebe Valdes, Kenneth W. Henry, Michael Q. Fitzgerald, Koushik Muralidharan, Andrew B. Caldwell, Srinivasan Ramachandran, Lawrence S. B. Goldstein, William C. Mobley, Douglas R. Galasko, Shankar Subramaniam
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Brain
Subjects:
Early-onset Alzheimer’s disease
iPSC neurons
RNA-seq
Systems biology
Online Access:https://doi.org/10.1186/s13041-023-01063-5

Internet

https://doi.org/10.1186/s13041-023-01063-5

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