Single‐Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma

Single‐Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Esophageal Squamous Cell Carcinoma

Abstract Lymph node metastasis, the leading cause of mortality in esophageal squamous carcinoma (ESCC) with a highly complex tumor microenvironment, remains underexplored. Here, the transcriptomes of 85 263 single cells are analyzed from four ESCC patients with lymph node metastases. Strikingly, it...

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Bibliographic Details
Main Authors: Yongxu Jia, Baifeng Zhang, Chunyang Zhang, Dora Lai‐Wan Kwong, Zhiwei Chang, Shanshan Li, Zehua Wang, Huiqiong Han, Jing Li, Yali Zhong, Xin Sui, Li Fu, Xinyuan Guan, Yanru Qin
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Advanced Science
Subjects:
bioinformatics
esophageal squamous carcinoma
immunofluorescence and immunohistochemistry
lymph node metastatic microenvironment
single cell RNA sequencing
Online Access:https://doi.org/10.1002/advs.202204565

Internet

https://doi.org/10.1002/advs.202204565

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