<i>GNAQ</i> and <i>GNA11</i> Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal Melanoma

<i>GNAQ</i> and <i>GNA11</i> Genes: A Comprehensive Review on Oncogenesis, Prognosis and Therapeutic Opportunities in Uveal Melanoma

The <i>GNAQ</i> and <i>GNA11</i> genes are mutated in almost 80–90% of uveal melanomas in a mutually exclusive pattern. These genes encode the alpha subunits of the heterotrimeric G proteins, Gq and G<sub>11</sub>; thus, mutations of these genes result in the acti...

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Bibliographic Details
Main Authors: Paula Silva-Rodríguez, Daniel Fernández-Díaz, Manuel Bande, María Pardo, Lourdes Loidi, María José Blanco-Teijeiro
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
uveal melanoma
mutation
<i>GNAQ</i>
<i>GNA11</i>
oncogenesis
prognostication
Online Access:https://www.mdpi.com/2072-6694/14/13/3066

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https://www.mdpi.com/2072-6694/14/13/3066

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