Structural basis to identify a target site in Shiga toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli

Structural basis to identify a target site in Shiga toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli

Abstract Background Certain peptides that bind Shiga toxin 2 (Stx2) have been reported to treat Shiga toxin-producing Escherichia coli (STEC) infections. However, their mechanisms of action remain unknown. STEC infections lead to serious diseases, such as hemolytic uremic syndrome, in humans. Antibi...

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Bibliographic Details
Main Authors: Anuja Prabhudesai, Samir Shaikh, Kayasth Zarna Ashwinbhai, Reeshu Gupta
Format: Article
Language:English
Published: SpringerOpen 2024-03-01
Series:Bulletin of the National Research Centre
Subjects:
Shiga toxin-producing E. coli
Tetravalent peptide
Antibiotics
Ribosome binding site
Ribosomal P-stalk
Online Access:https://doi.org/10.1186/s42269-024-01190-6

Internet

https://doi.org/10.1186/s42269-024-01190-6

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