Structural basis to identify a target site in Shiga toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli

Structural basis to identify a target site in Shiga toxin for the inhibitor discovery against growth of Shiga toxin-producing E. coli

Abstract Background Certain peptides that bind Shiga toxin 2 (Stx2) have been reported to treat Shiga toxin-producing Escherichia coli (STEC) infections. However, their mechanisms of action remain unknown. STEC infections lead to serious diseases, such as hemolytic uremic syndrome, in humans. Antibi...

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Bibliografiska uppgifter
Huvudupphovsmän: Anuja Prabhudesai, Samir Shaikh, Kayasth Zarna Ashwinbhai, Reeshu Gupta
Materialtyp: Artikel
Språk:English
Publicerad: SpringerOpen 2024-03-01
Serie:Bulletin of the National Research Centre
Ämnen:
Shiga toxin-producing E. coli
Tetravalent peptide
Antibiotics
Ribosome binding site
Ribosomal P-stalk
Länkar:https://doi.org/10.1186/s42269-024-01190-6

Internet

https://doi.org/10.1186/s42269-024-01190-6

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