Safety and Immunogenicity of M2-Deficient, Single Replication, Live Influenza Vaccine (M2SR) in Adults

Safety and Immunogenicity of M2-Deficient, Single Replication, Live Influenza Vaccine (M2SR) in Adults

M2SR (M2-deficient single replication) is an investigational live intranasal vaccine that protects against multiple influenza A subtypes in influenza-naïve and previously infected ferrets. We conducted a phase 1, first-in-human, randomized, dose-escalation, placebo-controlled study of M2SR safety an...

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Bibliographic Details
Main Authors: Joseph Eiden, Gilad Gordon, Carlos Fierro, Renee Herber, Roger Aitchison, Robert Belshe, Harry Greenberg, Daniel Hoft, Yasuko Hatta, Michael J. Moser, Magdalena Tary-Lehmann, Yoshihiro Kawaoka, Gabriele Neumann, Paul Radspinner, Pamuk Bilsel
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Vaccines
Subjects:
influenza
vaccine
clinical trial
M2SR
immunity
Online Access:https://www.mdpi.com/2076-393X/9/12/1388

Internet

https://www.mdpi.com/2076-393X/9/12/1388

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