Anti-Tumoral Effects of a (1<i>H</i>-Pyrrol-1-yl)Methyl-1<i>H</i>-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines

Anti-Tumoral Effects of a (1<i>H</i>-Pyrrol-1-yl)Methyl-1<i>H</i>-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines

Nocodazole is an antineoplastic agent that exerts its effects by depolymerizing microtubules. Herein we report a structural analog of nocodazole, a (1<i>H</i>-pyrrol-1-yl)methyl-1<i>H</i>-benzoimidazole carbamate ester derivative, named RDS 60. We evaluated the antineoplastic...

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Bibliographic Details
Main Authors: Alice Nicolai, Valentina Noemi Madia, Antonella Messore, Daniela De Vita, Alessandro De Leo, Davide Ialongo, Valeria Tudino, Elisabetta Tortorella, Luigi Scipione, Samanta Taurone, Tiziano Pergolizzi, Marco Artico, Roberto Di Santo, Roberta Costi, Susanna Scarpa
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
pyrroles
benzimidazoles
nocodazole
head and neck squamous cell carcinoma
apoptosis
epithelial-mesenchymal transition
Online Access:https://www.mdpi.com/1424-8247/14/6/564

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https://www.mdpi.com/1424-8247/14/6/564

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