Role of stromal PD-L1 expression in colorectal liver metastasis
Abstract Background and Aim The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we investigated the relationship between stromal programmed d...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-11869-8 |
| _version_ | 1797349841786896384 |
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| author | Chie Takasu Yuji Morine Kozo Yoshikawa Toshihiro Nakao Takuya Tokunaga Masaaki Nishi Hideya Kashihara Yuma Wada Toshiaki Yoshimoto Mitsuo Shimada |
| author_facet | Chie Takasu Yuji Morine Kozo Yoshikawa Toshihiro Nakao Takuya Tokunaga Masaaki Nishi Hideya Kashihara Yuma Wada Toshiaki Yoshimoto Mitsuo Shimada |
| author_sort | Chie Takasu |
| collection | DOAJ |
| description | Abstract Background and Aim The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we investigated the relationship between stromal programmed death-ligand 1 (PD-L1) expression and the prognosis of patients with colorectal cancer liver metastasis (CRLM). Methods The present study enrolled 84 CRLM patients who underwent surgery (R0) for CRC. Immunohistochemistry was performed to analyze stromal PD-L1 expression in CRLM. Results Stromal PD-L1 was expressed in 52.3% of CRLM samples, which was associated with fewer not optimally resectable metastases (p = 0.04). Stromal PD-L1 also tended to associate with a lower tumor grade (p = 0.08). Stromal PD-L1-positive patients had longer overall survival (p = 0.003). Multivariate analysis identified stromal PD-L1 expression (p = 0.008) and poorer differentiation (p < 0.001) as independent prognostic indicators. Furthermore, stromal PD-L1 expression was correlated to a high number of tumor-infiltrating lymphocytes (TILs). Stromal PD-L1– and low TIL groups had shorter OS than stromal PD-L1 + and high TIL groups (46.6% vs. 81.8%, p = 0.05) Stromal PD-L1-positive patients had longer disease-free survival (DFS) (p = 0.03) and time to surgical failure (p = 0.001). Interestingly, stromal PD-L1 expression was positively related to the desmoplastic subtype (p = 0.0002) and inversely related to the replacement subtype of the histological growth pattern (p = 0.008). Conclusions Stromal PD-L1 expression may be a significant prognostic marker for CRLM. |
| first_indexed | 2024-03-08T12:36:17Z |
| format | Article |
| id | doaj.art-3ebb0ea147854710b35428b2f1e35e21 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-08T12:36:17Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-3ebb0ea147854710b35428b2f1e35e212024-01-21T12:24:35ZengBMCBMC Cancer1471-24072024-01-0124111010.1186/s12885-024-11869-8Role of stromal PD-L1 expression in colorectal liver metastasisChie Takasu0Yuji Morine1Kozo Yoshikawa2Toshihiro Nakao3Takuya Tokunaga4Masaaki Nishi5Hideya Kashihara6Yuma Wada7Toshiaki Yoshimoto8Mitsuo Shimada9Department of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityDepartment of Surgery, Tokushima UniversityAbstract Background and Aim The outcomes of immune checkpoint blockade for colorectal cancer (CRC) treatment are unsatisfactory. Furthermore, the efficacy of immune checkpoint blockade for liver metastasis of various cancer is poor. Here, we investigated the relationship between stromal programmed death-ligand 1 (PD-L1) expression and the prognosis of patients with colorectal cancer liver metastasis (CRLM). Methods The present study enrolled 84 CRLM patients who underwent surgery (R0) for CRC. Immunohistochemistry was performed to analyze stromal PD-L1 expression in CRLM. Results Stromal PD-L1 was expressed in 52.3% of CRLM samples, which was associated with fewer not optimally resectable metastases (p = 0.04). Stromal PD-L1 also tended to associate with a lower tumor grade (p = 0.08). Stromal PD-L1-positive patients had longer overall survival (p = 0.003). Multivariate analysis identified stromal PD-L1 expression (p = 0.008) and poorer differentiation (p < 0.001) as independent prognostic indicators. Furthermore, stromal PD-L1 expression was correlated to a high number of tumor-infiltrating lymphocytes (TILs). Stromal PD-L1– and low TIL groups had shorter OS than stromal PD-L1 + and high TIL groups (46.6% vs. 81.8%, p = 0.05) Stromal PD-L1-positive patients had longer disease-free survival (DFS) (p = 0.03) and time to surgical failure (p = 0.001). Interestingly, stromal PD-L1 expression was positively related to the desmoplastic subtype (p = 0.0002) and inversely related to the replacement subtype of the histological growth pattern (p = 0.008). Conclusions Stromal PD-L1 expression may be a significant prognostic marker for CRLM.https://doi.org/10.1186/s12885-024-11869-8Immune check pointStromaPD-1 |
| spellingShingle | Chie Takasu Yuji Morine Kozo Yoshikawa Toshihiro Nakao Takuya Tokunaga Masaaki Nishi Hideya Kashihara Yuma Wada Toshiaki Yoshimoto Mitsuo Shimada Role of stromal PD-L1 expression in colorectal liver metastasis BMC Cancer Immune check point Stroma PD-1 |
| title | Role of stromal PD-L1 expression in colorectal liver metastasis |
| title_full | Role of stromal PD-L1 expression in colorectal liver metastasis |
| title_fullStr | Role of stromal PD-L1 expression in colorectal liver metastasis |
| title_full_unstemmed | Role of stromal PD-L1 expression in colorectal liver metastasis |
| title_short | Role of stromal PD-L1 expression in colorectal liver metastasis |
| title_sort | role of stromal pd l1 expression in colorectal liver metastasis |
| topic | Immune check point Stroma PD-1 |
| url | https://doi.org/10.1186/s12885-024-11869-8 |
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