Hyperinflammatory Immune Response in COVID-19: Host Genetic Factors in Pyrin Inflammasome and Immunity to Virus in a Spanish Population from Majorca Island

Hyperinflammatory Immune Response in COVID-19: Host Genetic Factors in Pyrin Inflammasome and Immunity to Virus in a Spanish Population from Majorca Island

The hyperinflammatory response caused by SARS-CoV-2 infection contributes to its severity, and many critically ill patients show features of cytokine storm (CS) syndrome. We investigated, by next-generation sequencing, 24 causative genes of primary immunodeficiencies whose defect predisposes to CS....

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Bibliographic Details
Main Authors: Natalia Martínez-Pomar, Vanesa Cunill, Marina Segura-Guerrero, Elisabet Pol-Pol, Danilo Escobar Oblitas, Jaime Pons, Ignacio Ayestarán, Patricia C. Pruneda, Inés Losada, Nuria Toledo-Pons, Mercedes García Gasalla, Joana Maria Ferrer Balaguer
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomedicines
Subjects:
hyperinflammatory immune response
Pyrin
COVID-19
primary immunodeficiency
cytokine storm
genetic markers
Online Access:https://www.mdpi.com/2227-9059/11/9/2548

Internet

https://www.mdpi.com/2227-9059/11/9/2548

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